SP1 monoclonal, anti-human
€0.00
In stock
SKU
AC-AM8422b
Catalog Number: AC-AM8422b
Size: 80 µl, 400 µl
Isotype: mouse IgG1,κ
Clone Name: 1326CT463.109.176
Applications: IF, FC, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: mouse IgG1,κ
Clone Name: 1326CT463.109.176
Applications: IF, FC, WB
Datasheet
Request Information
Background:
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.
Other Names:
Transcription factor Sp1, SP1, TSFP1
Target/Specificity:
This SP1 antibody is generated from a mouse immunized with a recombination protein from the human SP1.
Antigen Region:
1-250
Antigen Type: Recombinant Protein
Gene Name: SP1
Gene ID: 6667
Primary Accession: P08047
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.
Other Names:
Transcription factor Sp1, SP1, TSFP1
Target/Specificity:
This SP1 antibody is generated from a mouse immunized with a recombination protein from the human SP1.
Antigen Region:
1-250
Antigen Type: Recombinant Protein
Gene Name: SP1
Gene ID: 6667
Primary Accession: P08047
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
| Is Featured? | No |
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