SP100 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS7899
Background:
The human SP100 gene encodes an autoantigen that co-localizes with PML and NDP52 in distinct nuclear domains, called nuclear dots (NDs) or ND10 nuclear bodies. Papova-, adeno-, and herpesviruses begin their transcription and DNA-replication at NDs, which play a role in autoimmunity, viral infections and in the etiology of acute promyelocytic leukemia. SP-100 is an interferon-inducible protein that has two splice variants. One splice variant contains a highly conserved copy of the DNA-binding high mobility group 1 protein sequence, and thus represents a novel HMG-box protein. This alternatively spliced variant of SP-100 has a unique expression and localization pattern that is distinct from the SP-100 full-length protein. The SP100 protein is covalently modified by the small ubiquitin-related protein SUMO-1. SP-100 contains a functional nuclear localization signal and an ND-targeting region, which overlaps with the SP-100 homodimerization domain. The homodimerization/ND-targeting region is considered a novel protein motif, termed HSR domain. SP-100 is also found to interact with Bright (B cell regulator of IgH transcription), which in lymphoid cells also interacts with LYSP100/SP140, the lymphoid-restricted homolog of SP100.
Alternative Name:
Lysp100b, Nuclear antigen Sp100, Nuclear autoantigen Sp 100, Nuclear autoantigen Sp-100, Nuclear autoantigen Sp100, Nuclear dot associated Sp100 protein, Nuclear dot-associated Sp100 protein, SP 100, SP100, SP100 HMG nuclear autoantigen, SP100 nuclear antigen, SP100_HUMAN, Speckled 100 kDa,
Application Dilution: WB: 1:500 - 1:2000
Specificity: SP100 polyclonal antibody detects endogenous levels of SP100 protein.
Immunogen:
Recombinant full length Human SP100.
MW: ~ 54, 100 kDa
Swis Prot.: P23497
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The human SP100 gene encodes an autoantigen that co-localizes with PML and NDP52 in distinct nuclear domains, called nuclear dots (NDs) or ND10 nuclear bodies. Papova-, adeno-, and herpesviruses begin their transcription and DNA-replication at NDs, which play a role in autoimmunity, viral infections and in the etiology of acute promyelocytic leukemia. SP-100 is an interferon-inducible protein that has two splice variants. One splice variant contains a highly conserved copy of the DNA-binding high mobility group 1 protein sequence, and thus represents a novel HMG-box protein. This alternatively spliced variant of SP-100 has a unique expression and localization pattern that is distinct from the SP-100 full-length protein. The SP100 protein is covalently modified by the small ubiquitin-related protein SUMO-1. SP-100 contains a functional nuclear localization signal and an ND-targeting region, which overlaps with the SP-100 homodimerization domain. The homodimerization/ND-targeting region is considered a novel protein motif, termed HSR domain. SP-100 is also found to interact with Bright (B cell regulator of IgH transcription), which in lymphoid cells also interacts with LYSP100/SP140, the lymphoid-restricted homolog of SP100.
Alternative Name:
Lysp100b, Nuclear antigen Sp100, Nuclear autoantigen Sp 100, Nuclear autoantigen Sp-100, Nuclear autoantigen Sp100, Nuclear dot associated Sp100 protein, Nuclear dot-associated Sp100 protein, SP 100, SP100, SP100 HMG nuclear autoantigen, SP100 nuclear antigen, SP100_HUMAN, Speckled 100 kDa,
Application Dilution: WB: 1:500 - 1:2000
Specificity: SP100 polyclonal antibody detects endogenous levels of SP100 protein.
Immunogen:
Recombinant full length Human SP100.
MW: ~ 54, 100 kDa
Swis Prot.: P23497
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review