SPPL2B Blocking Peptide (Center)

Background:
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF- alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity.

Other Names:
Signal peptide peptidase-like 2B, SPP-like 2B, SPPL2b, 3423-, Intramembrane protease 4, IMP-4, Presenilin homologous protein 4, PSH4, Presenilin-like protein 1, SPPL2B, IMP4, KIAA1532, PSL1

Target/Specificity:
The synthetic peptide sequence is selected from aa 196-209 of HUMAN SPPL2B

Gene Name: SPPL2B {ECO:0000303|PubMed:15385547, ECO:0000312|HGNC:HGNC:30627}

Gene ID: 56928
Primary Accession: Q8TCT7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.