SPTBN5 polyclonal, anti-human
€305.00
In stock
SKU
BS61279
Background:
Whole-exome sequencing (WES) identified 46 non-synonymous and 13 synonymous somatic single-nucleotide polymorphisms (SNPs) and one frameshift deletion in the coding regions. Specifically, mutations of CDKN2A, TP53, SPTBN5, NOTCH2, and FAM136A were found in the databases. Copy number aberration (CNA) analysis revealed that the cell line loses chromosome 3p and 9p, but lacks amplification of 3q and 11q (as does HPV-negative, smoking-unrelated OTSCC). It also exhibits four distinctive focal amplifications in chromosome 19p, containing 131 genes without SNPs. Particularly, 52 genes showed >3- to 4-fold amplification and could be potential oncogenic drivers.
Alternative Name:
Spectrin beta chain, non-erythrocytic 5, Beta-V spectrin, SPTBN5, BSPECV, HUBSPECV, HUSPECV
Application Dilution: WB: 1:500~1:1000
Specificity: SPTBN5 pAb detects endogenous levels of SPTBN5 protein.
Immunogen:
Synthetic peptide, corresponding Human SPTBN5.
MW: ~ 416 kDa
Swis Prot.: Q9NRC6
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Whole-exome sequencing (WES) identified 46 non-synonymous and 13 synonymous somatic single-nucleotide polymorphisms (SNPs) and one frameshift deletion in the coding regions. Specifically, mutations of CDKN2A, TP53, SPTBN5, NOTCH2, and FAM136A were found in the databases. Copy number aberration (CNA) analysis revealed that the cell line loses chromosome 3p and 9p, but lacks amplification of 3q and 11q (as does HPV-negative, smoking-unrelated OTSCC). It also exhibits four distinctive focal amplifications in chromosome 19p, containing 131 genes without SNPs. Particularly, 52 genes showed >3- to 4-fold amplification and could be potential oncogenic drivers.
Alternative Name:
Spectrin beta chain, non-erythrocytic 5, Beta-V spectrin, SPTBN5, BSPECV, HUBSPECV, HUSPECV
Application Dilution: WB: 1:500~1:1000
Specificity: SPTBN5 pAb detects endogenous levels of SPTBN5 protein.
Immunogen:
Synthetic peptide, corresponding Human SPTBN5.
MW: ~ 416 kDa
Swis Prot.: Q9NRC6
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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