SQSTM1 (clone 5H7E2), anti-human

Background:
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Research Area: Epigenetics and nuclear signaling, Cancer, Signal transduction, Cardiovascular, Metabolism

Synonyms: p60, p62, A170, OSIL, PDB3, ZIP3, p62B

Immunogen: Purified recombinant fragment of human SQSTM1 (AA: 232-356) expressed in E. Coli.

Formulation: Purified antibody in PBS with 0.05% sodium azide

Storage:
4°C|-20°C for long term storage