Sqstm1(S351) Blocking Peptide
€363.00
In stock
SKU
AC-BP20690b
Background:
Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.
Other Names:
Sequestosome-1, STONE14, Ubiquitin-binding protein p62, Sqstm1, A170, STAP
Target/Specificity:
The synthetic peptide sequence is selected from aa 346-359 of HUMAN Sqstm1
Gene Name: Sqstm1 {ECO:0000303|PubMed:16286508, ECO:0000312|MGI:MGI:107931}
Gene ID: 18412
Primary Accession: Q64337
Other Accession: O08623; Q13501
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.
Other Names:
Sequestosome-1, STONE14, Ubiquitin-binding protein p62, Sqstm1, A170, STAP
Target/Specificity:
The synthetic peptide sequence is selected from aa 346-359 of HUMAN Sqstm1
Gene Name: Sqstm1 {ECO:0000303|PubMed:16286508, ECO:0000312|MGI:MGI:107931}
Gene ID: 18412
Primary Accession: Q64337
Other Accession: O08623; Q13501
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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