SRA (clone 1D4H8), anti-human
€478.00
In stock
SKU
252655
Protein Family: Transcription Factors
Pathway and Disease: Transcription
Description:
SRA (Steroid receptor RNA activator 1) is a 237-amino acid protein (~27kDa), belongs to the growing family of functional non-coding RNAs. SRA was originally described as the first functional noncoding RNA able to specifically coactivate the activity of steroid receptors. Specifically, SRA exists as both an RNA transcript that forms a complex with steroid receptor coactivator-1 and as a stably expressed protein. Its expression is strongly up-regulated in many human tumors of the breast, uterus and ovary, suggesting a potential role in pathogenesis. Although coactivation of steroid-dependent transcription by SRA is accompanied by a proliferative response, overexpression is not in itself sufficient to induce turmorigenesis.
Alternate Names: Steroid receptor RNA activator 1, Steroid receptor RNA activator protein, SRAP, SRA1
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: Q9HD15
Antigen: Purified recombinant fragment of SRA expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Transcription
Description:
SRA (Steroid receptor RNA activator 1) is a 237-amino acid protein (~27kDa), belongs to the growing family of functional non-coding RNAs. SRA was originally described as the first functional noncoding RNA able to specifically coactivate the activity of steroid receptors. Specifically, SRA exists as both an RNA transcript that forms a complex with steroid receptor coactivator-1 and as a stably expressed protein. Its expression is strongly up-regulated in many human tumors of the breast, uterus and ovary, suggesting a potential role in pathogenesis. Although coactivation of steroid-dependent transcription by SRA is accompanied by a proliferative response, overexpression is not in itself sufficient to induce turmorigenesis.
Alternate Names: Steroid receptor RNA activator 1, Steroid receptor RNA activator protein, SRAP, SRA1
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: Q9HD15
Antigen: Purified recombinant fragment of SRA expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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