SRC8 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP9247a
Background:
SRC8 is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This protein has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this protein contributes to tumor cell invasion and metastasis.
Other Names:
Src substrate cortactin, Amplaxin, Oncogene EMS1, CTTN, EMS1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP9247a was selected from the N-term region of human SRC8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CTTN
Gene ID: 2017
Primary Accession: Q14247
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
SRC8 is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This protein has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this protein contributes to tumor cell invasion and metastasis.
Other Names:
Src substrate cortactin, Amplaxin, Oncogene EMS1, CTTN, EMS1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP9247a was selected from the N-term region of human SRC8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CTTN
Gene ID: 2017
Primary Accession: Q14247
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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