SRD5A1 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61336
Background:
Steroid 5α-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5α-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, which is expressed mainly in the skin; and type 2, which is expressed mainly in the prostate. In cultured human skin cells, 5α-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5α-Reductase 1 is expressed in all portions of the hair follicle, whereas 5α-Reductase 2 is expressed only in mesenchymal portions. In addition, 5α-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5α-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5α-Reductase-3α-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.
Alternative Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC:1.3.1.22), SR type 1, Steroid 5-alpha-reductase 1, S5AR 1, SRD5A1
Application Dilution: WB: 1:500~1:1000
Specificity: SRD5A1 polyclonal antibody detects endogenous levels of SRD5A1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human SRD5A1.
MW: ~ 29 kDa
Swis Prot.: P18405
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Steroid 5α-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5α-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, which is expressed mainly in the skin; and type 2, which is expressed mainly in the prostate. In cultured human skin cells, 5α-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5α-Reductase 1 is expressed in all portions of the hair follicle, whereas 5α-Reductase 2 is expressed only in mesenchymal portions. In addition, 5α-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5α-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5α-Reductase-3α-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.
Alternative Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC:1.3.1.22), SR type 1, Steroid 5-alpha-reductase 1, S5AR 1, SRD5A1
Application Dilution: WB: 1:500~1:1000
Specificity: SRD5A1 polyclonal antibody detects endogenous levels of SRD5A1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human SRD5A1.
MW: ~ 29 kDa
Swis Prot.: P18405
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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