SRD5A1 polyclonal, anti-human, rat
€305.00
In stock
SKU
BS60411
Background:
In cultured human skin cells, 5a-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5a-Reductase 1 is expressed in all portions of the hair follicle, whereas 5a-Reductase 2 is expressed only in mesenchymal portions. In addition, 5a-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5a-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5a-Reductase-3a-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.
Alternative Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1, SR type 1, Steroid 5-alpha-reductase 1, S5AR 1
Application Dilution: WB: 1:500~1:1000
Specificity: SRD5A1 polyclonal antibody detects endogenous levels of SRD5A1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human SRD5A1.
MW: ~ 23 kDa
Swis Prot.: P18405
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
In cultured human skin cells, 5a-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5a-Reductase 1 is expressed in all portions of the hair follicle, whereas 5a-Reductase 2 is expressed only in mesenchymal portions. In addition, 5a-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5a-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5a-Reductase-3a-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.
Alternative Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1, SR type 1, Steroid 5-alpha-reductase 1, S5AR 1
Application Dilution: WB: 1:500~1:1000
Specificity: SRD5A1 polyclonal antibody detects endogenous levels of SRD5A1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human SRD5A1.
MW: ~ 23 kDa
Swis Prot.: P18405
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review