SRPK1 antibody (M10) (4G12), anti-human
€375.00
In stock
SKU
AC-AT4041a
Background:
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.
Isotype: mouse IgG2b Kappa
Other Names:
SRSF protein kinase 1, SFRS protein kinase 1, Serine/arginine-rich protein-specific kinase 1, SR-protein-specific kinase 1, SRPK1 {ECO:0000312|EMBL:CAC392991}
Antigen Type: Recombinant Protein
Target/Specificity:
SRPK1 (AAH38292, 371 a.a. ~ 470 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Gene Description: SFRS protein kinase 1
Gene Summary:
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. A second alternatively spliced transcript variant for this gene has been described, but its full length nature has not been determined. [provided by RefSeq
Primary Accession: Q96SB4
Other Accession: BC038292
Org Accession: AAH38292
NCBI Accession: NP_003128.3
Gene ID: 6732
Gene Name: SRPK1 {ECO:0000312|EMBL:CAC39299.1}
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Bio References:
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2. Tsianou D, et al. FEBS J, 2009 Sep. PMID 19674106.Arginine methylation of the ICP27 RGG box regulates the functional interactions of ICP27 with SRPK1 and Aly/REF during herpes simplex virus 1 infection. Souki SK, et al. J Virol, 2009 Sep. PMID 19553338.Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1. Ma CT, et al. J Mol Biol, 2009 Jul 24. PMID 19477182.Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Zhong XY, et al. Genes Dev, 2009 Feb 15. PMID 19240134.
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.
Isotype: mouse IgG2b Kappa
Other Names:
SRSF protein kinase 1, SFRS protein kinase 1, Serine/arginine-rich protein-specific kinase 1, SR-protein-specific kinase 1, SRPK1 {ECO:0000312|EMBL:CAC392991}
Antigen Type: Recombinant Protein
Target/Specificity:
SRPK1 (AAH38292, 371 a.a. ~ 470 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Gene Description: SFRS protein kinase 1
Gene Summary:
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. A second alternatively spliced transcript variant for this gene has been described, but its full length nature has not been determined. [provided by RefSeq
Primary Accession: Q96SB4
Other Accession: BC038292
Org Accession: AAH38292
NCBI Accession: NP_003128.3
Gene ID: 6732
Gene Name: SRPK1 {ECO:0000312|EMBL:CAC39299.1}
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Bio References:
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2. Tsianou D, et al. FEBS J, 2009 Sep. PMID 19674106.Arginine methylation of the ICP27 RGG box regulates the functional interactions of ICP27 with SRPK1 and Aly/REF during herpes simplex virus 1 infection. Souki SK, et al. J Virol, 2009 Sep. PMID 19553338.Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1. Ma CT, et al. J Mol Biol, 2009 Jul 24. PMID 19477182.Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Zhong XY, et al. Genes Dev, 2009 Feb 15. PMID 19240134.
| Is Featured? | No |
|---|
Write Your Own Review