E2F-1 (Acetyl-K125) polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP63285
Catalog Number: AC-AP72623
Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IP
Datasheet
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Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IP
Datasheet
Request Information
Background:
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599).
Other Names:
Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)
Antigen Type: synthetic peptide
Antigen Type: E2F1 {ECO:0000303|PubMed:8964493, ECO:0000312|HGNC:HGNC:3113}
Gene ID: 1869
Primary Accession: Q01094
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599).
Other Names:
Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)
Antigen Type: synthetic peptide
Antigen Type: E2F1 {ECO:0000303|PubMed:8964493, ECO:0000312|HGNC:HGNC:3113}
Gene ID: 1869
Primary Accession: Q01094
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