STAT2 Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13749a
Background:
The protein encoded by this gene is a member of the STATprotein family. In response to cytokines and growth factors, STATfamily members are phosphorylated by the receptor associatedkinases, and then form homo- or heterodimers that translocate tothe cell nucleus where they act as transcription activators. Inresponse to interferon (IFN), this protein forms a complex withSTAT1 and IFN regulatory factor family protein p48 (ISGF3G), inwhich this protein acts as a transactivator, but lacks the abilityto bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP)has been shown to interact specifically with this protein, which isthought to be involved in the process of blocking IFN-alpharesponse by adenovirus. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Other Names:
Signal transducer and activator of transcription 2, p113, STAT2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13749a was selected from the N-term region of STAT2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: STAT2
Gene ID: 6773
Primary Accession: P52630
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is a member of the STATprotein family. In response to cytokines and growth factors, STATfamily members are phosphorylated by the receptor associatedkinases, and then form homo- or heterodimers that translocate tothe cell nucleus where they act as transcription activators. Inresponse to interferon (IFN), this protein forms a complex withSTAT1 and IFN regulatory factor family protein p48 (ISGF3G), inwhich this protein acts as a transactivator, but lacks the abilityto bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP)has been shown to interact specifically with this protein, which isthought to be involved in the process of blocking IFN-alpharesponse by adenovirus. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Other Names:
Signal transducer and activator of transcription 2, p113, STAT2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13749a was selected from the N-term region of STAT2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: STAT2
Gene ID: 6773
Primary Accession: P52630
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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