STAT3 antibody (clone 4D6), anti-human
€435.00
In stock
SKU
AC-AT4062a
Catalog Number: AC-AT4062a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IF, E
Request Information AC-AT4062a">Request Information
Background:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Other Names:
Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3, APRF
Antigen Type:
Recombinant Protein
Gene Name: STAT3 {ECO:0000303|PubMed:9630560, ECO:0000312|HGNC:HGNC:11364}
Gene ID: 6774
NCBI Accession: NP_003141.2;NP_644805.1;NP_998827.1
Primary Accession: P40763
Other Accession: NM_003150
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Other Names:
Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3, APRF
Antigen Type:
Recombinant Protein
Gene Name: STAT3 {ECO:0000303|PubMed:9630560, ECO:0000312|HGNC:HGNC:11364}
Gene ID: 6774
NCBI Accession: NP_003141.2;NP_644805.1;NP_998827.1
Primary Accession: P40763
Other Accession: NM_003150
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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