STAT3 (clone 3F4), anti-human, mouse, rat
€295.00
In stock
SKU
K000233M
Catalog Number: K000233M
Size: 100 μl
Other size: 50 μl
Isotype: Mouse IgG1
Applications: WB, IHC
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Size: 100 μl
Other size: 50 μl
Isotype: Mouse IgG1
Applications: WB, IHC
Request Manual
Questions? Contact us!
Background:
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene . May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1. Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation . Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.
Synonyms: ADMIO, ADMIO1, APRF, HIES, ADMIO, APRF, HIES
Cellular Location: Cytoplasm Nucleus
Immunogen:
Recombinant Protein
Gene Symbol: STAT3
Gene ID: 6774
Swiss prot: P40763
Calculated MW: 79/86kDa
Recommended dilution:
WB 1:1000-2000, IHC 1:100-200
Purity:
Saturated ammonium sulfate precipitation
Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene . May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1. Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation . Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.
Synonyms: ADMIO, ADMIO1, APRF, HIES, ADMIO, APRF, HIES
Cellular Location: Cytoplasm Nucleus
Immunogen:
Recombinant Protein
Gene Symbol: STAT3
Gene ID: 6774
Swiss prot: P40763
Calculated MW: 79/86kDa
Recommended dilution:
WB 1:1000-2000, IHC 1:100-200
Purity:
Saturated ammonium sulfate precipitation
Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
| Is Featured? | No |
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