Stat5 (phospho Tyr694/699) Polyclonal Antibody

Background:
signal transducer and activator of transcription 5A(STAT5A) Homo sapiens The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been

Alternative Names:
STAT5A, STAT5, Signal transducer and activator of transcription 5A, STAT5B, Signal transducer and activator of transcription 5B

Immunogen: The antiserum was produced against synthesized peptide derived from human STAT5A around the phosphorylation site of Tyr694. AA range:666-715

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 91

GeneID: STAT5A/STAT5B

Storage: -20°C/1 year

NOTE: For Research Use Only