STAT5B antibody (clone 5D6), anti-human
€435.00
In stock
SKU
AC-AT4065a
Catalog Number: AC-AT4065a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IHC, IF, E
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IHC, IF, E
Request Information AC-AT4065a">Request Information
Background:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Other Names:
Signal transducer and activator of transcription 5B, STAT5B
Antigen Type:
Recombinant Protein
Gene Name: STAT5B
Gene ID: 6777
NCBI Accession: NP_036580.2
Primary Accession: P51692
Other Accession: NM_012448
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Other Names:
Signal transducer and activator of transcription 5B, STAT5B
Antigen Type:
Recombinant Protein
Gene Name: STAT5B
Gene ID: 6777
NCBI Accession: NP_036580.2
Primary Accession: P51692
Other Accession: NM_012448
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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