Stat5b polyclonal, anti-human, rat
€388.00
In stock
SKU
BS6031
Background:
Stat5a and Stat5b (signal transducer and activator of transcription 5a and 5b; 96% homology) undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus where they initiate transcription. Activation of Stat5b via IL-2, IL-4, CSF1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with retinoic acid receptor-α gene in acute promyelocytic leukemias (APLL).
Alternative Name:
Signal transducer and activator of transcription 5B, STA5B, STAT5, Stat5b, Transcription factor STAT5B,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: STAT5B polyclonal antibody detects endogenous levels of STAT5B protein.
Immunogen:
Recombinant full length Human Stat5b.
MW: ~ 90 kDa
Swis Prot.: P51692
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Stat5a and Stat5b (signal transducer and activator of transcription 5a and 5b; 96% homology) undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus where they initiate transcription. Activation of Stat5b via IL-2, IL-4, CSF1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with retinoic acid receptor-α gene in acute promyelocytic leukemias (APLL).
Alternative Name:
Signal transducer and activator of transcription 5B, STA5B, STAT5, Stat5b, Transcription factor STAT5B,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: STAT5B polyclonal antibody detects endogenous levels of STAT5B protein.
Immunogen:
Recombinant full length Human Stat5b.
MW: ~ 90 kDa
Swis Prot.: P51692
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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