STAU1 antibody (clone 3D8), anti-human
€435.00
In stock
SKU
AC-AT4068a
Catalog Number: AC-AT4068a
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IF, E
Request Information AC-AT4068a">Request Information
Background:
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.
Other Names:
Double-stranded RNA-binding protein Staufen homolog 1, STAU1, STAU
Antigen Type:
Recombinant Protein
Gene Name: STAU1
Gene ID: 6780
NCBI Accession: NP_001032405.1;NP_004593.2;NP_059346.2;NP_059347.2;NP_059348.2
Primary Accession: O95793
Other Accession: NM_004602
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.
Other Names:
Double-stranded RNA-binding protein Staufen homolog 1, STAU1, STAU
Antigen Type:
Recombinant Protein
Gene Name: STAU1
Gene ID: 6780
NCBI Accession: NP_001032405.1;NP_004593.2;NP_059346.2;NP_059347.2;NP_059348.2
Primary Accession: O95793
Other Accession: NM_004602
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
| Is Featured? | No |
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