STRADA cDNA
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In stock
SKU
ATGD0156
Description
STRADA encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. STRADA forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). STRADA activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. STRADA is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.Alternative Names
LYK5, NY-BR-96, PMSE, Stlk, STRADConcentration
LyophilizedStorage: Store the plasmid at -20C.
STRADA encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. STRADA forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). STRADA activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. STRADA is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.Alternative Names
LYK5, NY-BR-96, PMSE, Stlk, STRADConcentration
LyophilizedStorage: Store the plasmid at -20C.
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