STRAP polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS70705
Background:
STRAP, another antagonist to the TGFβ signalling pathway, specifically interacts with Smad7, but not Smad6, to synergistically block TGF∫-induced transcriptional activation. The gene encoding the human homolog of STRAP (as designated in mouse), called unr-interacting protein, maps to chromosome 12p12.3. Unr-interacting protein is 97% homologous to STRAP at the amino acid level. The unr-interacting protein binds unr, a cytoplasmic RNA-binding protein with five cold-shock domains that is involved in RNA translation. The presence of the STRAP gene in a variety of species from mammals to yeast, indicates that STRAP function is evolutionarily conserved in eukaryotic cells.
Alternative Name:
MAWD, PT-WD, UNRIP,
Application Dilution: WB: 1:1000 - 1:2000
Specificity: STRAP polyclonal antibody detects endogenous levels of STRAP protein.
Immunogen:
Recombinant protein of human STRAP.
MW: ~ 38 kDa
Swis Prot.: Q9Y3F4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
STRAP, another antagonist to the TGFβ signalling pathway, specifically interacts with Smad7, but not Smad6, to synergistically block TGF∫-induced transcriptional activation. The gene encoding the human homolog of STRAP (as designated in mouse), called unr-interacting protein, maps to chromosome 12p12.3. Unr-interacting protein is 97% homologous to STRAP at the amino acid level. The unr-interacting protein binds unr, a cytoplasmic RNA-binding protein with five cold-shock domains that is involved in RNA translation. The presence of the STRAP gene in a variety of species from mammals to yeast, indicates that STRAP function is evolutionarily conserved in eukaryotic cells.
Alternative Name:
MAWD, PT-WD, UNRIP,
Application Dilution: WB: 1:1000 - 1:2000
Specificity: STRAP polyclonal antibody detects endogenous levels of STRAP protein.
Immunogen:
Recombinant protein of human STRAP.
MW: ~ 38 kDa
Swis Prot.: Q9Y3F4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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