STUB1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6204
Background:
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation.
Alternative Name:
Antigen NY CO 7, Antigen NY-CO-7, Carboxy terminus of Hsp70 interacting protein, Carboxy terminus of Hsp70-interacting protein, Carboxy terminus of Hsp70p interacting protein, CHIP, CHIP, CLL associated antigen KW 8, CLL-associated antigen KW-8, E3 ubiquitin protein ligase CHIP, E3 ubiquitin-protein ligase CHIP, Heat shock protein A binding protein 2 (c terminal), HSPABP2, NY CO 7, SDCCAG7, Serologically defined colon cancer antigen 7, STIP1 homology and U Box containing protein 1, STIP1
Application Dilution: WB: 1:500 - 1:2000
Specificity: STUB1 polyclonal antibody detects endogenous levels of STUB1 protein.
Immunogen:
Recombinant full length Human STUB1.
MW: ~ 35 kDa
Swis Prot.: Q9UNE7
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation.
Alternative Name:
Antigen NY CO 7, Antigen NY-CO-7, Carboxy terminus of Hsp70 interacting protein, Carboxy terminus of Hsp70-interacting protein, Carboxy terminus of Hsp70p interacting protein, CHIP, CHIP, CLL associated antigen KW 8, CLL-associated antigen KW-8, E3 ubiquitin protein ligase CHIP, E3 ubiquitin-protein ligase CHIP, Heat shock protein A binding protein 2 (c terminal), HSPABP2, NY CO 7, SDCCAG7, Serologically defined colon cancer antigen 7, STIP1 homology and U Box containing protein 1, STIP1
Application Dilution: WB: 1:500 - 1:2000
Specificity: STUB1 polyclonal antibody detects endogenous levels of STUB1 protein.
Immunogen:
Recombinant full length Human STUB1.
MW: ~ 35 kDa
Swis Prot.: Q9UNE7
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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