SUN1 polyclonal, anti-human, rat

Background:
UNC84A (UNC84 homolog A), also known as SUN1, is a multi-pass nuclear membrane protein that is involved in nuclear anchoring and migration. Highly expressed in heart, brain and testis, UNC84A functions as an A-type Lamin-binding protein that forms a link between the inner and outer nuclear envelope membranes. This link acts as a structural bridge between the nuclear interior and the Actin cytoskeleton and is essential for proper localization of nuclear envelope proteins. Additionally, UNC84A may be involved in telomere attachment and in normal testis development. UNC84A contains one UNC84 (SUN) domain and exists as four isoforms due to alternative splicing events.

Alternative Name:
SUN domain-containing protein 1, Protein unc-84 homolog A, Sad1/unc-84 protein-like 1, SUN1, KIAA0810, UNC84A

Application Dilution: WB: 1:500-1:2000, IHC: 1:50-1:200, ICC: 1:50-1:200, FC: 1:50-1:100

Specificity: This antibody detects endogenous levels of SUN1 and does not cross-react with related proteins.

Immunogen:
Recombinant protein corresponding to C-terminal human SUN1.

MW: ~ 90 kDa

Swis Prot.: O94901

Purification & Purity:
Protein A affinity purified.

Format:
Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.