Surfactant protein A (clone 6F10), anti-human
€829.00
In stock
SKU
250400
Catalog Nr.: 250400
Size: 0.2 mg
Isotype: Mouse IgG1
Applications: E, WB, IHC
Datasheet
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Size: 0.2 mg
Isotype: Mouse IgG1
Applications: E, WB, IHC
Datasheet
Request Information
Protein Family: Glycan Binding Proteins
Pathway and Disease: Cell Growth and Death, Energy Metabolism
Description:
Surfactant protein A (SP-A) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular 'head' regions linked by triple-helical, collagen-like, strands. This group also includes SP-D and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages. The serum concentration is 45 ng/ml in healthy individuals. This antibody is specific for human pulmonary SP-A.
Alternate Names: Pulmonary surfactant-associated protein A1, SP-A1, SP-A, PSP-A, PSPA, Alveolar proteinosis protein, 35 kDa pulmonary surfactant-associated protein
Application Notes: Product Cat. No. 250400 reacts in western blot with reduced forms of SP-A, but weakly with non-reduced forms. Product Cat. No. 250400 reacts specifically with human SP-A in immunohistochemical staining of paraffin-embedded tissue samples. Immunoreactivity is seen in alveolar type II cells, nonciliated bronchial cells and a subset of alveolar macrophages. No reactivity is seen in samples from pancreas, intestines, thymus, prostate gland and peritoneal cavity-lining cells. Product Cat. No. 250400 reacts strongly in ELISA with SP-A directly coated onto the microtiter well. E: 1:16,000; WB: 1:1,000; IHC: 1:3,000
Accession No.: Q8IWL2
Antigen: Native SP-A purified from bronchioaveolar lavage from proteinosis patients
Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Tzouvelekis A et al. 2013. BioMed Research International. ID 654354
Pathway and Disease: Cell Growth and Death, Energy Metabolism
Description:
Surfactant protein A (SP-A) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular 'head' regions linked by triple-helical, collagen-like, strands. This group also includes SP-D and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages. The serum concentration is 45 ng/ml in healthy individuals. This antibody is specific for human pulmonary SP-A.
Alternate Names: Pulmonary surfactant-associated protein A1, SP-A1, SP-A, PSP-A, PSPA, Alveolar proteinosis protein, 35 kDa pulmonary surfactant-associated protein
Application Notes: Product Cat. No. 250400 reacts in western blot with reduced forms of SP-A, but weakly with non-reduced forms. Product Cat. No. 250400 reacts specifically with human SP-A in immunohistochemical staining of paraffin-embedded tissue samples. Immunoreactivity is seen in alveolar type II cells, nonciliated bronchial cells and a subset of alveolar macrophages. No reactivity is seen in samples from pancreas, intestines, thymus, prostate gland and peritoneal cavity-lining cells. Product Cat. No. 250400 reacts strongly in ELISA with SP-A directly coated onto the microtiter well. E: 1:16,000; WB: 1:1,000; IHC: 1:3,000
Accession No.: Q8IWL2
Antigen: Native SP-A purified from bronchioaveolar lavage from proteinosis patients
Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Tzouvelekis A et al. 2013. BioMed Research International. ID 654354
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