Surfactant protein D (clone 10B2), anti-human

Protein Family: Glycan Binding Proteins

Pathway and Disease: Immune System, Infectious Diseases

Description:
Surfactant protein D (SP-D) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular 'head' regions linked by triple-helical, collagen-like, strands. This group also includes SP-A and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages. The serum concentration is approximately 700 ng/ml in healthy individuals. This antibody is specific for SP-D from amniotic fluid, serum and bronchioalveolar lavage. The antibody blocks SP-D binding to GP-340 but not to carbohydrates.

Alternate Names: Pulmonary surfactant-associated protein D, SP-D, PSP-D, PSPD, Lung surfactant protein D

Application Notes: Product Cat. No. 250403 is used as detection antibody in sandwich ELISAwith a polyclonal antibody. Antibody binding is calcium-dependent. Product Cat. No. 250403 only reacts in western blot with non-reduced SP-D. E: 1:2,000; WB: 1:2,000

Accession No.: P35247

Antigen: Native human SP-D purified from late pregnancy amniotic fluid

Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.

Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.