Survivin (clone 2H5H2), anti-human

Protein Family: Enzymes

Pathway and Disease: Cancers, Cell Growth and Death, Replication and Repair, Signaling Molecules and Interaction

Description:
Survivin (Apoptosis inhibitor survivin) is a component of the chromosomal passenger complex (CPC), a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. CPC is required for chromatin-induced microtubule stabilization and spindle assembly. Survivin interacts with tubulin and inhibits caspase-3 and caspase-7. Survivin is abundantly expressed in adenocarcinoma and high-grade lymphomas.

Alternate Names: Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor survivin, Apoptosis inhibitor 4, BIRC5, API4, IAP4

Application Notes: WB: 1:500-1:2000

Accession No.: O15392

Antigen: Purified recombinant fragment of Survivin expressed in E. coli.

Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.