SVIL antibody (clone 60000000000), anti-human
€435.00
In stock
SKU
AC-AT4117a
Catalog Number: AC-AT4117a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
Request Information AC-AT4117a">Request Information
Background:
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described.
Other Names:
Supervillin, Archvillin, p205/p250, SVIL
Antigen Type:
Recombinant Protein
Gene Name: SVIL {ECO:0000303|PubMed:9867483}
Gene ID: 6840
NCBI Accession: NP_003165.2;NP_068506.2
Primary Accession: O95425
Other Accession: NM_003174
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described.
Other Names:
Supervillin, Archvillin, p205/p250, SVIL
Antigen Type:
Recombinant Protein
Gene Name: SVIL {ECO:0000303|PubMed:9867483}
Gene ID: 6840
NCBI Accession: NP_003165.2;NP_068506.2
Primary Accession: O95425
Other Accession: NM_003174
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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