SYK (clone 8C1A3), anti-human
€567.00
In stock
SKU
252775
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Cancers, Immune System, Signal Transduction, Signaling Molecules and Interaction
Description:
SYK (Spleen tyrosine kinase), along with Zap-70, is a member of the Syk family of cytoplasmic tyrosine kinases, containing a dual SH2 domain separated by a linker region. In B cells, SYK couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through phosphorylation/activation of phospholipase C-gamma, when phosphorylated on Tyr-348 and Tyr-352. Phosphorylation on Tyr-323 creates a binding site for c-Cbl, which is a negative regulator of BCR-stimulated calcium signaling. Also transmits signals from other cell surface receptors including the T-cell receptor, CD74, Fc receptor and integrins. Abnormal constitutive SYK activity has been implicated in some hematopoietic malignancies.
Alternate Names: SYK, Spleen Tyrosine Kinase, Tyrosine-protein kinase SYK
Application Notes: WB: 1:500-1:2000
Accession No.: P43405
Antigen: Purified recombinant fragment of SYK(aa296-484) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cancers, Immune System, Signal Transduction, Signaling Molecules and Interaction
Description:
SYK (Spleen tyrosine kinase), along with Zap-70, is a member of the Syk family of cytoplasmic tyrosine kinases, containing a dual SH2 domain separated by a linker region. In B cells, SYK couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through phosphorylation/activation of phospholipase C-gamma, when phosphorylated on Tyr-348 and Tyr-352. Phosphorylation on Tyr-323 creates a binding site for c-Cbl, which is a negative regulator of BCR-stimulated calcium signaling. Also transmits signals from other cell surface receptors including the T-cell receptor, CD74, Fc receptor and integrins. Abnormal constitutive SYK activity has been implicated in some hematopoietic malignancies.
Alternate Names: SYK, Spleen Tyrosine Kinase, Tyrosine-protein kinase SYK
Application Notes: WB: 1:500-1:2000
Accession No.: P43405
Antigen: Purified recombinant fragment of SYK(aa296-484) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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