Syk (phospho-Y525) polyclonal, anti-human, rat
€328.00
In stock
SKU
BS4189
Background:
Syk (spleen tyrosine kinase) is a 635 amino acid protein that contains one protein kinase domain and two SH2 domains. One of several members of the protein kinase superfamily, Syk functions as a positive effector of B cell antigen receptor (CD79)-stimulated responses, coupling CD79 with the movement of one calcium ion through one of two phospho-regulated pathways. Via its ability to influence CD79 activity and to control the movement of calicum through the cell, Syk plays an important role in a variety of cellular responses, including differentiation, phagocytosis, proliferation and B cell development. Syk expression is upregulated in T cell lymphoma, suggesting a possible role for Syk in tumorigenesis. Two isoforms of Syk, designated short and long, exist due to alternative splicing events.
Alternative Name:
Tyrosine-protein kinase SYK, Spleen tyrosine kinase, p72-Syk, SYK
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-Syk (Y525) polyclonal antibody detects endogenous levels of Syk protein only when phosphorylated at Tyr525.
Immunogen:
Synthetic phosphopeptide derived from human Syk around the phosphorylation site of Tyrosine 525.
MW: ~ 69 kDa
Swis Prot.: P43405
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Syk (spleen tyrosine kinase) is a 635 amino acid protein that contains one protein kinase domain and two SH2 domains. One of several members of the protein kinase superfamily, Syk functions as a positive effector of B cell antigen receptor (CD79)-stimulated responses, coupling CD79 with the movement of one calcium ion through one of two phospho-regulated pathways. Via its ability to influence CD79 activity and to control the movement of calicum through the cell, Syk plays an important role in a variety of cellular responses, including differentiation, phagocytosis, proliferation and B cell development. Syk expression is upregulated in T cell lymphoma, suggesting a possible role for Syk in tumorigenesis. Two isoforms of Syk, designated short and long, exist due to alternative splicing events.
Alternative Name:
Tyrosine-protein kinase SYK, Spleen tyrosine kinase, p72-Syk, SYK
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-Syk (Y525) polyclonal antibody detects endogenous levels of Syk protein only when phosphorylated at Tyr525.
Immunogen:
Synthetic phosphopeptide derived from human Syk around the phosphorylation site of Tyrosine 525.
MW: ~ 69 kDa
Swis Prot.: P43405
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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