Synaptophysin Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP2039a
Background:
Synaptophysin is a transmembrane glycoprotein present in neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body. This protein consists of four transmembrane domains, with its amino- and carboxyl-terminus facing the cytoplasm. Coltage-dependent channel activity is seen when synaptophysin hexamers are reconstituted into lipid membranes, reminiscent of gap-junction proteins. Synaptophysin appears to be a significant cholesterol-binding protein in brain synaptic vesicles. A regioselective downregulation of synaptophysin is found in patients with Alzheimer.s disease and schizophrenia.
Other Names:
Synaptophysin, Major synaptic vesicle protein p38, SYP
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2039a was selected from the N-term region of human Synaptophysin . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SYP
Gene ID: 6855
Primary Accession: P08247
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Synaptophysin is a transmembrane glycoprotein present in neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body. This protein consists of four transmembrane domains, with its amino- and carboxyl-terminus facing the cytoplasm. Coltage-dependent channel activity is seen when synaptophysin hexamers are reconstituted into lipid membranes, reminiscent of gap-junction proteins. Synaptophysin appears to be a significant cholesterol-binding protein in brain synaptic vesicles. A regioselective downregulation of synaptophysin is found in patients with Alzheimer.s disease and schizophrenia.
Other Names:
Synaptophysin, Major synaptic vesicle protein p38, SYP
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2039a was selected from the N-term region of human Synaptophysin . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SYP
Gene ID: 6855
Primary Accession: P08247
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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