SYVN1 Peptide
€100.00
In stock
SKU
350470
Protein Family: Enzymes, Ubiquitins
Pathway and Disease: Folding, Sorting and Degradation
Alternate Names: E3 ubiquitin-protein ligase synoviolin; Synovial apoptosis inhibitor 1; HRD1; SYVN1
Accession No.: Q86TM6, NP_115807
Description:
Synoviolin (SYVN1) acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates subsequently promoting their degradation. For instance, SYVN1 protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. SYVN1 is up-regulated in synovial tissues from patients with rheumatoid arthritis.
Format:
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
MW: 2048.1 g/mol
Sequence:
The synthetic peptide used to raise the antibody Cat. No. 200108 is selected from a sequence within the C-term region of human SYVN1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Composition:
C81H130N24O34S2
Purity:
> 80% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Pathway and Disease: Folding, Sorting and Degradation
Alternate Names: E3 ubiquitin-protein ligase synoviolin; Synovial apoptosis inhibitor 1; HRD1; SYVN1
Accession No.: Q86TM6, NP_115807
Description:
Synoviolin (SYVN1) acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates subsequently promoting their degradation. For instance, SYVN1 protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. SYVN1 is up-regulated in synovial tissues from patients with rheumatoid arthritis.
Format:
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
MW: 2048.1 g/mol
Sequence:
The synthetic peptide used to raise the antibody Cat. No. 200108 is selected from a sequence within the C-term region of human SYVN1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Composition:
C81H130N24O34S2
Purity:
> 80% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
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