TAB2 Blocking Peptide (C-term)

Background:
Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.

Other Names:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, TAB-2, TGF-beta-activated kinase 1-binding protein 2, TAB2, KIAA0733, MAP3K7IP2

Target/Specificity:
The synthetic peptide sequence is selected from aa 646-660 of HUMAN TAB2

Gene Name: TAB2 {ECO:0000303|PubMed:10882101, ECO:0000312|HGNC:HGNC:17075}

Gene ID: 23118
Primary Accession: Q9NYJ8
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.