TAG-72/CA72.4 [clone B72.3], anti-human, cow, dog, hamster, rat

Description: Tumor-Associated Glycoprotein 72 (TAG-72) is an oncofetal mucin antigen expressed by normal secretory endometrium and most human adenocarcinomas, including colorectal, gastric, pancreatic, mammary, and ovarian. Antibody B72.3 recognizes a carbohydrate epitope identified as sialylated Tn antigen. This antigen is expressed by invasive ductal breast carcinomas, colon, pancreatic, gastric, esophageal, lung, ovarian and endometrial adenocarcinomas. It is not expressed by leukemias, lymphomas, sarcomas, mesotheliomas, melanomas, or benign tumors. This antigen is also expressed on normal secretory endometrium, but not on other normal tissues. TAG-72 expression in fetal tissue is only observed in tissues of the gastrointestinal tract, including the colon, esophagus and stomach. No reactivity is seen with tissue from other organ systems, including the lymphoreticular, cardiovascular, hepatic, pulmonary, neural, muscular, skin, endocrine and genitourinary tissues.Localization: cytoplasm, membraneDilution: 50-200Positive Control: Breast caHIER: citrate pH6.0Status: RUO