TARDBP polyclonal, anti-human, mouse, rat

Background:
DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.

Alternative Name:
TAR DNA-binding protein 43, TDP-43, TARDBP, TDP43

Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200, IP/RIP: 1:50~1:200

Specificity: TARDBP polyclonal antibody detects endogenous levels of TARDBP protein.

Immunogen:
Recombinant full length Human TARDBP.

MW: ~ 45 kDa

Swis Prot.: Q13148

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.