TAT Peptide

Protein Family: Transcription Factors, Receptors and Channels

Pathway and Disease: Transcription, Signaling Molecules and Interactions, Infectious Diseases

Alternate Names: Tat protein; transactivator of transciption protein; transactivating regulatory protein

Accession No.: P04613

Description:
TAT protein is the nuclear transcriptional activator of viral gene expression in HIV proliferation. The TAT peptide corresponds to the polycationic aa49-57 region of TAT protein. TAT peptide is a cell-penetrating peptide (CPP) used to cargo larger molecules through the lipophilic barrier of the cellular membranes to deliver them inside the cells with intact biological activity. These peptides are also known as protein transduction domains (PTD).

Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

MW: 1558.88 g/mol

Sequence:
Human: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2 or H-YGRKKRRQRRR-NH2

Composition:
C64H119N33O13

Purity:
> 95% by HPLC

Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.