Tau-13 (clone B11E8 ), anti-human antibody
€390.00
In stock
SKU
AC-ABV10332-100
Catalog Number: AC-ABV10332-100
Size: 100 µl
Host: Mouse IgG
Applications: WB, IHC, IP
Datasheet
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Size: 100 µl
Host: Mouse IgG
Applications: WB, IHC, IP
Datasheet
Request Information
Background:
Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is tho µght to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimer’s disease.
Other Names:
FLJ31424 , FTDP 17 , FTDP17 , MSTD , MAPT
Primary Accession: P10636
Gene Name: MAPT
Gene ID: 4137
Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is tho µght to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimer’s disease.
Other Names:
FLJ31424 , FTDP 17 , FTDP17 , MSTD , MAPT
Primary Accession: P10636
Gene Name: MAPT
Gene ID: 4137
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