TBC1D4 (phospho-T642) polyclonal, anti-human, rat
€328.00
In stock
SKU
BS4293
Background:
TBC1 domain family member 4 (TBC1D4), also designated AS160, can be insulin- and/or AKT1-induced. Insulin-stimulated phosphorylation is required for GLUT4 translocation. TBC1D4 may play a role as a GTPase activating protein for proteins in the Rab family. It is expressed primarily in skeletal muscle and heart, as well as spleen, lymph node and leukocytes. Defects in the TBC1D4 gene may cause atopic dermatitis (AD), sometimes referred to as eczema, an atopic chronic skin disease. The skin of affected individuals reacts to irritants or allergens and becomes red, flaky and itchy. The skin is also more vulnerable to inflammations, and symptoms can grow or disappear over time.
Alternative Name:
TBC1 domain family member 4, Akt substrate of 160 kDa, TBC1D4, AS160, KIAA0603
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: p-TBC1D4 (T642) polyclonal antibody detects endogenous levels of TBC1D4 only when phosphorylated at Thr642.
Immunogen:
Synthetic phosphopeptide derived from human TBC1D4 around the phosphorylation site of Threonine 642.
MW: ~ 160 kDa
Swis Prot.: O60343
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
TBC1 domain family member 4 (TBC1D4), also designated AS160, can be insulin- and/or AKT1-induced. Insulin-stimulated phosphorylation is required for GLUT4 translocation. TBC1D4 may play a role as a GTPase activating protein for proteins in the Rab family. It is expressed primarily in skeletal muscle and heart, as well as spleen, lymph node and leukocytes. Defects in the TBC1D4 gene may cause atopic dermatitis (AD), sometimes referred to as eczema, an atopic chronic skin disease. The skin of affected individuals reacts to irritants or allergens and becomes red, flaky and itchy. The skin is also more vulnerable to inflammations, and symptoms can grow or disappear over time.
Alternative Name:
TBC1 domain family member 4, Akt substrate of 160 kDa, TBC1D4, AS160, KIAA0603
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: p-TBC1D4 (T642) polyclonal antibody detects endogenous levels of TBC1D4 only when phosphorylated at Thr642.
Immunogen:
Synthetic phosphopeptide derived from human TBC1D4 around the phosphorylation site of Threonine 642.
MW: ~ 160 kDa
Swis Prot.: O60343
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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