TBP Monoclonal Antibody

Background:
This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
GTF2D, GTF2D1, HDL4, SCA17, TATA binding factor, TATA box binding protein, TATA box factor, TATA sequence binding protein, TATA sequence-binding protein, TATA-binding factor, TATA-box factor, TATA-box-binding protein, TBP, TBP, TFIID, Transcription initiation factor TFIID TBP subunit

Immunogen: Recombinant Protein

Swissprot: P20226

Purification Method: Protein A purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: IHC 1:50-200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.