TBX-2 (clone 4D6), anti-human
€564.00
In stock
SKU
ARP-21-5255
Catalog Number: 21-5255
Size: 100 µg
Isotype: Mouse IgG1
Size: 100 µg
Isotype: Mouse IgG1
Background:
T-box transcription factor TBX2 is a protein that in Humans is encoded by the TBX2 gene and with subcellulairlocation in the nucleus. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the Human homolog of Mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indiCate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. In melanocytic cell types, expression of the T-box 2 gene is regulated by the Microphthalmia-associated transcription factor The oncogene TBX2 is a coopeRating factor in transformation of pocket protein deficient MEFs. TBX2 downregulates the p53/p21CIP1 pathway both in wild-type and pocket protein deficient MEFs. Tissue specificity: expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.
Clone: 4D6
Isotype: Mouse IgG1
Source: 4D6 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with a GST fusion protein corresponding to residues 554-702 of Human TBX2.
Reactivity: human
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Immunoprecipitation, Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
T-box transcription factor TBX2 is a protein that in Humans is encoded by the TBX2 gene and with subcellulairlocation in the nucleus. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the Human homolog of Mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indiCate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. In melanocytic cell types, expression of the T-box 2 gene is regulated by the Microphthalmia-associated transcription factor The oncogene TBX2 is a coopeRating factor in transformation of pocket protein deficient MEFs. TBX2 downregulates the p53/p21CIP1 pathway both in wild-type and pocket protein deficient MEFs. Tissue specificity: expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.
Clone: 4D6
Isotype: Mouse IgG1
Source: 4D6 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with a GST fusion protein corresponding to residues 554-702 of Human TBX2.
Reactivity: human
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Immunoprecipitation, Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
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