TCEB2 antibody (clone 6F6), anti-human, rat
€435.00
In stock
SKU
AC-AT4179a
Catalog Number: AC-AT4179a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, Ehttps://www.abcepta.com/products/pdf_download/AT4179a-TCEB2-Antibody-monoclonal-M01">Request Information AC-AT4179a">Request Information
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, Ehttps://www.abcepta.com/products/pdf_download/AT4179a-TCEB2-Antibody-monoclonal-M01">Request Information AC-AT4179a">Request Information
Background:
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.
Other Names:
Transcription elongation factor B polypeptide 2, Elongin 18 kDa subunit, Elongin-B, EloB, RNA polymerase II transcription factor SIII subunit B, SIII p18, TCEB2
Antigen Type:
Recombinant Protein
Gene Name: ELOB (HGNC:11619)
Gene ID: 6923
NCBI Accession: NP_009039.1;NP_996896.1
Primary Accession: Q15370
Other Accession: NM_007108
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.
Other Names:
Transcription elongation factor B polypeptide 2, Elongin 18 kDa subunit, Elongin-B, EloB, RNA polymerase II transcription factor SIII subunit B, SIII p18, TCEB2
Antigen Type:
Recombinant Protein
Gene Name: ELOB (HGNC:11619)
Gene ID: 6923
NCBI Accession: NP_009039.1;NP_996896.1
Primary Accession: Q15370
Other Accession: NM_007108
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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