TCL1 (clone 1-21) APC, anti-human RUO

Introduction:
TCL1, also known as T-cell leukemia/lymphoma protein 1A, protein p14 TCL1 and oncogene TCL-1, is a 14kD beta-barrel protein that was originally identified on the basis of its association with T-cell prolymphocytic leukemia (T-PLL). Activated by the T-cell receptor enhancer through inv(14)(q11;q32.1) or t(14;14)(q11;q32.1), TCL1 is normally expressed in immature cortical thymocytes, activated peripheral T-cells, pro-B cells, and naive mantle zone B cells of peripheral lymphoid tissues, but not in post-germinal center (GC) memory B cells and plasma cells. Akt and TCL1 interact via Akt’s pleckstrin homology domain to form hetero-oligomers at the leaflet of the inner plasma membrane stimulating the protein kinase C-mitogen activated protein kinase-extracellular signal-related kinase (PKC-MAPK-ERK) signal transduction pathway. TCL1 also inhibits activation-induced cell death in T-cells by blocking PKCθ. In addition to T-PLL dysregulation is implicated in such B-cell neoplasias as lymphoblastic lymphoma, chronic lymphocytic leukemia (CLL) and Burkitt lymphoma.

Recomended usage
Immunostep’s anti-human T cell leukemia/lymphoma 1 (TCL1) antibody, clone 1-21, is a monoclonal antibody designed for the identification and enumeration of TCL1 protein, a 14 kDa proto-oncogene product involved in the intracellular regulation of T cell signaling.
This antibody is intended for use in flow cytometry to detect TCL1 expression in various cell types, including immature cortical thymocytes, activated peripheral T cells, pro-B cells, and naive mantle zone B cells of peripheral lymphoid tissues.

Application: FCM

Storage Temperature: Store in the dark at 2-8 °C

Shelf life: Each reagent is stable until the expiration date shown on the bottle label when stored as directed (at least, one year)