TCL1A antibody (clone 3A4), anti-human
€435.00
In stock
SKU
AC-AT4195a
Catalog Number: AC-AT4195a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: E
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: E
Request Information AC-AT4195a">Request Information
Background:
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).
Other Names:
T-cell leukemia/lymphoma protein 1A, Oncogene TCL-1, Oncogene TCL1, Protein p14 TCL1, TCL1A, TCL1
Antigen Type:
Recombinant Protein
Gene Name: TCL1A
Gene ID: 8115
NCBI Accession: NP_001092195.1;NP_068801.1
Primary Accession: P56279
Other Accession: NM_021966
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).
Other Names:
T-cell leukemia/lymphoma protein 1A, Oncogene TCL-1, Oncogene TCL1, Protein p14 TCL1, TCL1A, TCL1
Antigen Type:
Recombinant Protein
Gene Name: TCL1A
Gene ID: 8115
NCBI Accession: NP_001092195.1;NP_068801.1
Primary Accession: P56279
Other Accession: NM_021966
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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