TDP1 Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP17653c
Background:
The protein encoded by this gene is involved in repairingstalled topoisomerase I-DNA complexes by catalyzing the hydrolysisof the phosphodiester bond between the tyrosine residue oftopoisomerase I and the 3-prime phosphate of DNA. This protein mayalso remove glycolate from single-stranded DNA containing 3-primephosphoglycolate, suggesting a role in repair of free-radicalmediated DNA double-strand breaks. This gene is a member of thephospholipase D family and contains two PLD phosphodiesterasedomains. Mutations in this gene are associated with the diseasespinocerebellar ataxia with axonal neuropathy (SCAN1). Whileseveral transcript variants may exist for this gene, thefull-length natures of only two have been described to date. Thesetwo represent the major variants of this gene and encode the sameisoform.
Other Names:
Tyrosyl-DNA phosphodiesterase 1, Tyr-DNA phosphodiesterase 1, 314-, TDP1
Gene Name: TDP1
Gene ID: 55775
Primary Accession: Q9NUW8
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is involved in repairingstalled topoisomerase I-DNA complexes by catalyzing the hydrolysisof the phosphodiester bond between the tyrosine residue oftopoisomerase I and the 3-prime phosphate of DNA. This protein mayalso remove glycolate from single-stranded DNA containing 3-primephosphoglycolate, suggesting a role in repair of free-radicalmediated DNA double-strand breaks. This gene is a member of thephospholipase D family and contains two PLD phosphodiesterasedomains. Mutations in this gene are associated with the diseasespinocerebellar ataxia with axonal neuropathy (SCAN1). Whileseveral transcript variants may exist for this gene, thefull-length natures of only two have been described to date. Thesetwo represent the major variants of this gene and encode the sameisoform.
Other Names:
Tyrosyl-DNA phosphodiesterase 1, Tyr-DNA phosphodiesterase 1, 314-, TDP1
Gene Name: TDP1
Gene ID: 55775
Primary Accession: Q9NUW8
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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