TDP1 antibody (clone 2A10-G2), anti-human
€435.00
In stock
SKU
AC-AT4200a
Catalog Number: AC-AT4200a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, E
Request Information AC-AT4200a">Request Information
Background:
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
Other Names:
Tyrosyl-DNA phosphodiesterase 1, Tyr-DNA phosphodiesterase 1, 314-, TDP1
Antigen Type:
Recombinant Protein
Gene Name: TDP1
Gene ID: 55775
NCBI Accession: NP_001008744.1;NP_060789.2
Primary Accession: Q9NUW8
Other Accession: BC015474
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
Other Names:
Tyrosyl-DNA phosphodiesterase 1, Tyr-DNA phosphodiesterase 1, 314-, TDP1
Antigen Type:
Recombinant Protein
Gene Name: TDP1
Gene ID: 55775
NCBI Accession: NP_001008744.1;NP_060789.2
Primary Accession: Q9NUW8
Other Accession: BC015474
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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