Tensin-1 (phospho-Y483) polyclonal, anti-human, mouse
€328.00
In stock
SKU
BS4831
Background:
Tensin is involved in the maintenance of cellular structure by anchoring Actin filaments at the focal adhesion via F-Actin binding and capping activities. However, tensin also contains a Src homology 2 (SH2) domain and has the ability to be phosphorylated. Tensin is phosphorylated on tyrosine, serine, and threonine residues, suggesting that it might participate in signal transduction cascades. These diverse characteristics in a single molecule indicate that tensin may be an important link between the cytoskeleton and signal transduction pathways.
Alternative Name:
Tensin-1, TNS1, TNS
Application Dilution: IHC: 1:50~1:200
Specificity: p-Tensin-1 (Y483) polyclonal antibody detects endogenous levels of Tensin-2 protein when phosphorylated at Tyr483.
Immunogen:
Synthetic phosphopeptide derived from human Tensin-1 around the phosphorylation site of Tyrosine 483.
MW: ~ 152, 230 kDa
Swis Prot.: Q9HBL0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Tensin is involved in the maintenance of cellular structure by anchoring Actin filaments at the focal adhesion via F-Actin binding and capping activities. However, tensin also contains a Src homology 2 (SH2) domain and has the ability to be phosphorylated. Tensin is phosphorylated on tyrosine, serine, and threonine residues, suggesting that it might participate in signal transduction cascades. These diverse characteristics in a single molecule indicate that tensin may be an important link between the cytoskeleton and signal transduction pathways.
Alternative Name:
Tensin-1, TNS1, TNS
Application Dilution: IHC: 1:50~1:200
Specificity: p-Tensin-1 (Y483) polyclonal antibody detects endogenous levels of Tensin-2 protein when phosphorylated at Tyr483.
Immunogen:
Synthetic phosphopeptide derived from human Tensin-1 around the phosphorylation site of Tyrosine 483.
MW: ~ 152, 230 kDa
Swis Prot.: Q9HBL0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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