Tetranectin (clone 6F9), anti-human
€829.00
In stock
SKU
250352
Catalog Nr.: 250352
Size: 0.2 mg
Isotype: Mouse IgG2a/k
Applications: E, WB
Datasheet
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Size: 0.2 mg
Isotype: Mouse IgG2a/k
Applications: E, WB
Datasheet
Request Information
Protein Family: Proteoglycans, Enzymes
Pathway and Disease: Development and Behavior
Description:
Tetranectin (TN) is a serum and tissue protein, a C-type lectin, which binds to Ca++. It is a homotrimer of monomers each with a mass of 20 kDa, plasma or serum concentrations of TN are found to be approximately 10 mg/l. In vitro, TN can bind to kringle 4 of plasminogen and enhance the activation of plaminogen to plasmin, catalyzed by tissue plasminogen activator in the presence of poly-D-lysine. TN is best known as a prognostic marker in ovarian cancer. This antibody is specific for amino acids 17-181 of human tetranectin monomer.
Alternate Names: TN, C-type lectin domain family 3 member B, Plasminogen kringle 4-binding protein
Application Notes: Product Cat. No. 250352 reacts strongly with tetranectin in sandwich ELISA as capture antibody in combination with a polyclonal antibody or Product Cat. No. 250350. Product Cat. No. 350352 reacts strongly in western blot with TN monomer and slightly with TN trimer. Product Cat. No. 250352 shows no staining for TN in fresh frozen tissues of ovarian cancer and paraffin-embeded, microwave treated tissues. E: 1:2,000; WB: 1:200
Accession No.: P05452
Antigen: Tetranectin purified from human citrate plasma (3) and coupled to PPD. Boosted before fusion with recombinant tetranectin produced in E. coli.
Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Development and Behavior
Description:
Tetranectin (TN) is a serum and tissue protein, a C-type lectin, which binds to Ca++. It is a homotrimer of monomers each with a mass of 20 kDa, plasma or serum concentrations of TN are found to be approximately 10 mg/l. In vitro, TN can bind to kringle 4 of plasminogen and enhance the activation of plaminogen to plasmin, catalyzed by tissue plasminogen activator in the presence of poly-D-lysine. TN is best known as a prognostic marker in ovarian cancer. This antibody is specific for amino acids 17-181 of human tetranectin monomer.
Alternate Names: TN, C-type lectin domain family 3 member B, Plasminogen kringle 4-binding protein
Application Notes: Product Cat. No. 250352 reacts strongly with tetranectin in sandwich ELISA as capture antibody in combination with a polyclonal antibody or Product Cat. No. 250350. Product Cat. No. 350352 reacts strongly in western blot with TN monomer and slightly with TN trimer. Product Cat. No. 250352 shows no staining for TN in fresh frozen tissues of ovarian cancer and paraffin-embeded, microwave treated tissues. E: 1:2,000; WB: 1:200
Accession No.: P05452
Antigen: Tetranectin purified from human citrate plasma (3) and coupled to PPD. Boosted before fusion with recombinant tetranectin produced in E. coli.
Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
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