TFDP1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7264
Background:
The human retinoblastoma gene product appears to play an important role in the negative egulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus-encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 forms heterodimers with a second protein, designated DP-1, forming an “active” E2F transcriptional regulatory complex. Additional members of the E2F family include E2F-2, E2F-3, E2F-4, E2F-5 and DP-2.
Alternative Name:
DP - 1 Transcription Factor, E2F dimerization partner 1, DRTF1-polypeptide 1, DRTF1, DP1, 7027, TFDP1, 189902, Q14186, DP1, DRTF1, Dp-1,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: TFDP1 polyclonal antibody detects endogenous levels of TFDP1 protein.
Immunogen:
Recombinant full length Human TFDP1.
MW: ~ 55 kDa
Swis Prot.: Q14186
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The human retinoblastoma gene product appears to play an important role in the negative egulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus-encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 forms heterodimers with a second protein, designated DP-1, forming an “active” E2F transcriptional regulatory complex. Additional members of the E2F family include E2F-2, E2F-3, E2F-4, E2F-5 and DP-2.
Alternative Name:
DP - 1 Transcription Factor, E2F dimerization partner 1, DRTF1-polypeptide 1, DRTF1, DP1, 7027, TFDP1, 189902, Q14186, DP1, DRTF1, Dp-1,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: TFDP1 polyclonal antibody detects endogenous levels of TFDP1 protein.
Immunogen:
Recombinant full length Human TFDP1.
MW: ~ 55 kDa
Swis Prot.: Q14186
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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