TFE3 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5962
Background:
The DNA-binding factor TFE3 contains adjacent helix-loop-helix (HLH) and leucine zipper (LZ) domains flanked by an upstream basic region. These protein motifs are frequently observed in other transcription factors and are particularly common to members of the Myc family. TFE3 is ubiquitously expressed and can directly associates with DNA as either homodimers or heterodimers formed with two related proteins, TFEB or TFEC. TFE3 binds to and activates the microE3 motif of the immunoglobulin heavy-chain enhancer to induce B-cell-specific gene transcription and DNA recombination. TFEB binds to the major late promoter of adenovirus and specifically associates with DNA as both a homodimer and a heterodimer with TFE3. TFEB is expressed at low levels in the embryo but at high levels in the trophoblast cells of the placenta, where it plays a critical role in regulating normal vascularization of the placenta.
Alternative Name:
Transcription factor E3, Class E basic helix-loop-helix protein 33, bHLHe33, TFE-3, BHLHE33
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, ICC: 1:50~1:200
Specificity: TFE3 polyclonal antibody detects endogenous levels of TFE3 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 133-178 of Human TFE3.
MW: ~ 62 kDa
Swis Prot.: P19532
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The DNA-binding factor TFE3 contains adjacent helix-loop-helix (HLH) and leucine zipper (LZ) domains flanked by an upstream basic region. These protein motifs are frequently observed in other transcription factors and are particularly common to members of the Myc family. TFE3 is ubiquitously expressed and can directly associates with DNA as either homodimers or heterodimers formed with two related proteins, TFEB or TFEC. TFE3 binds to and activates the microE3 motif of the immunoglobulin heavy-chain enhancer to induce B-cell-specific gene transcription and DNA recombination. TFEB binds to the major late promoter of adenovirus and specifically associates with DNA as both a homodimer and a heterodimer with TFE3. TFEB is expressed at low levels in the embryo but at high levels in the trophoblast cells of the placenta, where it plays a critical role in regulating normal vascularization of the placenta.
Alternative Name:
Transcription factor E3, Class E basic helix-loop-helix protein 33, bHLHe33, TFE-3, BHLHE33
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, ICC: 1:50~1:200
Specificity: TFE3 polyclonal antibody detects endogenous levels of TFE3 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 133-178 of Human TFE3.
MW: ~ 62 kDa
Swis Prot.: P19532
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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