TFRC monoclonal, anti-human
€0.00
In stock
SKU
AC-AM2075b
Catalog Number: AC-AM2075b
Size: 80 µl, 400 µl
Isotype: mouse IgM
Clone Name: 514CT23.4.1
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: mouse IgM
Clone Name: 514CT23.4.1
Applications: WB
Datasheet
Request Information
Background:
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Other Names:
Transferrin receptor protein 1, TR, TfR, TfR1, Trfr, T9, p90, CD71, Transferrin receptor protein 1, serum form, sTfR, TFRC
Target/Specificity:
This TFRC antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 649-677 amino acids from human TFRC.
Antigen Region:
649-677
Antigen Type: Synthetic Peptide
Gene Name: TFRC
Gene ID: 7037
Primary Accession: P02786
NCBI Accession: NP_001121620.1;NP_003225.2
Other Accession: NP_001121620.1
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Other Names:
Transferrin receptor protein 1, TR, TfR, TfR1, Trfr, T9, p90, CD71, Transferrin receptor protein 1, serum form, sTfR, TFRC
Target/Specificity:
This TFRC antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 649-677 amino acids from human TFRC.
Antigen Region:
649-677
Antigen Type: Synthetic Peptide
Gene Name: TFRC
Gene ID: 7037
Primary Accession: P02786
NCBI Accession: NP_001121620.1;NP_003225.2
Other Accession: NP_001121620.1
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
| Is Featured? | No |
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