TGF-beta-3 human active recombinant protein
€295.00
In stock
SKU
600172
Protein Family: CAM Ligands, Cytokines
Pathway and Disease: Cancers, Cell Growth and Death, Signal Transduction, Signaling Molecules and Interaction
Alternate Names: Transforming growth factor beta-3, TGF-beta-3, TGFB3Description:
Transforming growth factor-beta (TGF beta) consists of multifunctional peptides that regulate growth and differentiation in a variety of cells. The transforming growth factor beta (TGF-beta) family of growth modulators play critical roles in tissue development and maintenance. Recent data suggest that individual TGF-beta isoforms (TGF-beta 1, -beta 2 and -beta 3) have overlapping yet distinct biological actions and target cell specificities, both in developing and adult tissues Transforming growth factor (TGF) beta 3 is a new isoform of the TGF beta superfamily and is presumed to play an important role in wound repair and scarring. TGF-beta 3 is believed to be involved in osteoblast proliferation, chemotaxis, and collagen synthesis. Defects in TGF-beta 3 are a cause of familial arrhythmogenic right ventricular dysplasia type 1 (ARVD1), also known as arrhythmogenic right ventricular cardiomyopathy. ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. Recombinant Human TGF-b 3 produced in E. coli is a disulfide-linked homodimeric non-glycosylated polypeptide chain containing 112 amino acids with a MW of 25,445 Da.
Source: E. coli. Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
Applications: E, WB
Application Notes:
TGF-beta 3 is fully biologically active when compared to standard. The ED50 as determined by the cell toxicity assay using the WHO Standard 98/608 as a direct comparison is < 0.05ng/ml.
Accession No.: P10600
MW: 25445 Da
Sequence:
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS
Purity:
Purity > 98% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Format:
Each vial contains 10 ug protein in 20% ethanol, 0.12% acetic acid at a concentration of 0.25 mg/ml.
Storage: Store at 4°C. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Cancers, Cell Growth and Death, Signal Transduction, Signaling Molecules and Interaction
Alternate Names: Transforming growth factor beta-3, TGF-beta-3, TGFB3Description:
Transforming growth factor-beta (TGF beta) consists of multifunctional peptides that regulate growth and differentiation in a variety of cells. The transforming growth factor beta (TGF-beta) family of growth modulators play critical roles in tissue development and maintenance. Recent data suggest that individual TGF-beta isoforms (TGF-beta 1, -beta 2 and -beta 3) have overlapping yet distinct biological actions and target cell specificities, both in developing and adult tissues Transforming growth factor (TGF) beta 3 is a new isoform of the TGF beta superfamily and is presumed to play an important role in wound repair and scarring. TGF-beta 3 is believed to be involved in osteoblast proliferation, chemotaxis, and collagen synthesis. Defects in TGF-beta 3 are a cause of familial arrhythmogenic right ventricular dysplasia type 1 (ARVD1), also known as arrhythmogenic right ventricular cardiomyopathy. ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. Recombinant Human TGF-b 3 produced in E. coli is a disulfide-linked homodimeric non-glycosylated polypeptide chain containing 112 amino acids with a MW of 25,445 Da.
Source: E. coli. Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
Applications: E, WB
Application Notes:
TGF-beta 3 is fully biologically active when compared to standard. The ED50 as determined by the cell toxicity assay using the WHO Standard 98/608 as a direct comparison is < 0.05ng/ml.
Accession No.: P10600
MW: 25445 Da
Sequence:
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS
Purity:
Purity > 98% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Format:
Each vial contains 10 ug protein in 20% ethanol, 0.12% acetic acid at a concentration of 0.25 mg/ml.
Storage: Store at 4°C. Product is guaranteed one year from the date of shipment.
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